Publié par Administrateur le 27-10-2008 02:07
#1
USMLE est United State Médical Licensing Examination est l'examen d'accès à la spécialité aux USA.
Il comporte trois étapes :
1ère étape :
Les sciences initiales
Anatomie, science comportementale, biochimie, pharmacologie, physio, physiopath, génétique, nutrition, biologie moléculaire et cellulaire, immunologie....
La liste des cours à préparer dans la biochimie et la biologie moléculaire:
Code
Biochemistry and molecular biology
• gene expression: DNA structure, replication, and exchange
– DNA structure: single- and double-stranded DNA, stabilizing forces, supercoiling
– analysis of DNA: sequencing, restriction analysis, PCR amplification, hybridization
– DNA replication, mutation, repair, degradation, and inactivation
– gene structure and organization; chromosomes; centromere, telomere
– recombination, insertion sequences, transposons
– mechanisms of genetic exchange, including transformation, transduction, conjugation, crossover,
recombination, linkage
– plasmids and bacteriophages
• gene expression: transcription, including defects
– transcription of DNA into RNA, enzymatic reactions, RNA, RNA degradation
– regulation: cis-regulatory elements, transcription factors, enhancers, promoters, silencers, repressants,
splicing
• gene expression: translation, including defects
– the genetic code
– structure and function of tRNA
– structure and function of ribosomes
– protein synthesis
– regulation of translation
– post-translational modifications, including phosphorylation, addition of CHO units
– protein degradation
• structure and function of proteins
– principles of protein structure and folding
– enzymes: kinetics, reaction mechanisms
– structural and regulatory proteins: ligand binding, self-assembly
– regulatory properties
• energy metabolism, including metabolic sequences and regulation
– generation of energy from carbohydrates, fatty acids, and essential amino acids; glycolysis, pentose
phosphate pathway, tricarboxylic acid cycle, ketogenesis, electron transport and oxidative phosphorylation,
glycogenolysis
– storage of energy: gluconeogenesis, glycogenesis, fatty acid and triglyceride synthesis
– thermodynamics: free energy, chemical equilibria and group transfer potential, energetics of ATP and
other high-energy compounds
• metabolic pathways of small molecules and associated diseases
– biosynthesis and degradation of amino acids (eg, homocystinuria, maple syrup urine disease)
– biosynthesis and degradation of purine and pyrimidine nucleotides
– biosynthesis and degradation of lipids (eg, dyslipidemias, carnitine deficiency, adrenogenital
syndromes)
– biosynthesis and degradation of porphyrins
– galactosemia and other small sugar disorders
– biosynthesis and degradation of alcohols and other small molecules
• biosynthesis and degradation of other macromolecules and associated abnormalities, complex
carbohydrates (eg, lysosomal storage disease), glycoproteins, and proteoglycans (eg, type II glycogen storage
disease)
Toute la liste des cours : http://download.u...8step1.pdf
Il s'agit de questions à choix multiples, intégré dans un programme informatique..
Et pour passer l'examen lorsqu'on est des étrangers on doit s'enregistrer sur ce site: http://www.ecfmg....
Pour le préparer voici un logiciel qui va vous aider :
En effet on peut se préparer à cet examen à l'aide d'un logiciel disponible sur cette http://download.u...ep1mcq.zip
Exemple de question:
Code
A 32-year-old woman with type 1 diabetes
mellitus has had progressive renal failure over the
past 2 years. She has not yet started dialysis.
Examination shows no abnormalities. Her
hemoglobin concentration is 9 g/dL, hematocrit is
28%, and mean corpuscular volume is 94 μm3. A
blood smear shows normochromic, normocytic
cells. Which of the following is the most likely
cause?
(A) Acute blood loss
(B) Chronic lymphocytic leukemia
(C) Erythrocyte enzyme deficiency
(D) Erythropoietin deficiency
(E) Immunohemolysis
(F) Microangiopathic hemolysis
(G) Polycythemia vera
(H) Sickle cell disease
(I) Sideroblastic anemia
(J) β-Thalassemia trait
(Answer: D)