Sujet de la discussion : MedeSpace.Net :: United State Médical Licensing Examination

Publié par La Pharmacienne le 15-02-2009 03:24
#40

The answer is a, Congenital cytomegalovirus infection.

Thrombocytopenia and hemolytic anemia, as seen in this patient, are common manifestations of the "TORCH" (toxoplasmosis, other, rubella, cytomegalovirus, and herpes simplex) infections as well as congenital syphilis. Both increased platelet destruction and impaired production of platelets may be the mechanisms involved.

Some mothers who have had ITP and who have high levels of antiplatelet antibody in the maternal plasma can give birth to thrombocytopenic infants because of transplacental crossing of antiplatelet IgG antibody. The syndrome of congenital amegakaryocytic thrombocytopenia and bilateral absence of the radii (thrombocytopenia-absent radius, or TAR, syndrome) is a well-known entity.

Maternal ingestion of aspirin can lead to bleeding in the newborn, not as a result of thrombocytopenia but as a consequence of transient impairment of the infant's platelet aggregation. Neither chlamydial conjunctivitis nor nasolacrimal duct stenosis is usually associated with thrombocytopenia.